Home Immunology & Inflammation Immunology & Inflammation related chemical Quercitrin For research use only.

Quercitrin

Synonyms: 3-rhamnosyl quercetin, Sophoretin, Meletin, Xanthaurine

Quercitrin (3-rhamnosyl quercetin, Sophoretin, Meletin, Xanthaurine), a glycoside of quercetin, has been found as a main bioactive constituent in T. sinensis leaves and has antioxidant, anti-inflammatory, and anti-allergic activities.

Quercitrin Chemical Structure

Quercitrin Chemical Structure

CAS No. 522-12-3

Purity & Quality Control

Quercitrin Related Products

Biological Activity

Description Quercitrin (3-rhamnosyl quercetin, Sophoretin, Meletin, Xanthaurine), a glycoside of quercetin, has been found as a main bioactive constituent in T. sinensis leaves and has antioxidant, anti-inflammatory, and anti-allergic activities.
In vitro
In vitro

Quercitrin ameliorates cytokine-impaired viability of RINm5F cells and improves Glucose-stimulated insulin secretion in cytokine-treated RINm5F cells. It also reduces production of cellular ROS from cytokines and restrains the enhancement of NO production caused by cytokines in RINm5F cells via inhibition of iNOS expression[1].
Cell Research Cell lines The insulin-secreting cell line RINm5F
Concentrations 0, 5, 10 and 20 μM
Incubation Time 2 h
Method

Cells are cultured in DMEM with 10% FBS, 100 U/ml penicillin, 100 μg/ml streptomycin, 2 mmol/l in a humidified atmosphere (5% CO2, 37°C). After starvation for 24 h, cells are treated with quercetin or quercitrin (0, 5, 10 and 20 μM) for 2 h, then co-incubated with TNF-α (10 ng/ml), IL-1β (5 ng/ml) and IFN-γ (1,000 U/ml) for 24 h.
In Vivo
In vivo

Quercitrin significantly suppresses the elevation of reactive oxygen species (ROS) production and malondialdehyde (MDA) content, reduces tissue plasminogen activator (t-PA) activity, enhances the antioxidant enzyme activities and abrogates cytochrome P450 2E1 (CYP2E1) induction in mouse brains. Quercitrin also prevents CCl4 induced cerebral function disorders associated with its ability to inhibit the activities of monoamine oxidase (MAO), acetylcholine esterase (AChE) and the N-methyl-D-aspartate receptor 2B subunit (NR2B). Quercitrin is known to have biological effects such as anti-oxidative, anti-inflammatory, and anti-apoptosis effects and it might be a more potent antioxidant and a neuroprotective agent than quercetin due to its high bioavailability in the digestive track. Quercitrin significantly reduces acute systemic inflammation in LPS-induced models as well as attenuates inflammation in the livers of mice. Quercitrin could also reduce inflammation and apoptosis in cytokine-induced models. In streptozotocin (STZ)-induced diabetic models, quercitrin displays organ protective properties in the pancreas, liver and kidney by improving the antioxidant status[2].
Animal Research Animal Models Male ICR mice
Dosages 50 and 100 mg/kg
Administration Oral gavage

Chemical Information & Solubility

Molecular Weight 448.38 Formula

C21H20O11
CAS No. 522-12-3 SDF Download Quercitrin SDF
Smiles CC1C(C(C(C(O1)OC2=C(OC3=CC(=CC(=C3C2=O)O)O)C4=CC(=C(C=C4)O)O)O)O)O
Storage (From the date of receipt)

In vitro
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DMSO : 89 mg/mL ( (198.49 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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